Dipyridamole injection

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Description

Dipyridamole is a coronary vasodilator described as 2,2/,2//,2///-[(4,8-Dipiperidinopyrimido [5,4- d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol. It has the following structural formula:

Molecular Weight 504.64
Chemical Structure

Dipyridamole injection is an odorless, pale yellow liquid which can be diluted in sodium chloride injection or dextrose injection and water for intravenous administration.

Dipyridamole injection is provided as a sterile solution for intravenous administration.

Each mL contains: Dipyridamole USP, 5 mg; polyethylene glycol 600, 50 mg; tartaric acid, 2 mg.

The pH is adjusted to 2.7 0.5 with hydrochloric acid.

Clinical pharmacology

In a study of 10 patients with angiographically normal or minimally stenosed (less than 25% luminal diameter narrowing) coronary vessels, dipyridamole injection (dipyridamole USP), in a dose of 0.56 mg/kg infused over 4 minutes, resulted in an average five-fold increase in coronary blood flow velocity compared to resting coronary flow velocity (range 3.8 to 7 times resting velocity). The mean time to peak flow velocity was 6.5 minutes from the start of the 4-minute infusion (range 2.5 to 8.7 minutes). Cardiovascular responses to the intravenous administration of dipyridamole injection when given to patients in the supine position include a mild but significant increase in heart rate of approximately 20% and mild but significant decreases in both systolic and diastolic blood pressure of approximately 28%, with vital signs returning to baseline values in approximately 30 minutes.

Mechanism of action

Dipyridamole injection is a coronary vasodilator in man. The mechanism of vasodilation has not been fully elucidated but may result from inhibition of uptake of adenosine, an important mediator of coronary vasodilation. The vasodilatory effects of dipyridamole injection are abolished by administration of the adenosine receptor antagonist theophylline.

How dipyridamole injection-induced vasodilation leads to abnormalities in thallium distribution and ventricular function is also uncertain but presumably represents a "steal" phenomenon in which relatively intact vessels dilate, and sustain enhanced flow, leaving reduced pressure and flow across areas of hemodynamically important coronary vascular constriction.

Pharmacokinetics and metabolism

Plasma dipyridamole concentrations decline in a triexponential fashion following intravenous infusion of dipyridamole injection with half-lives averaging 312 minutes, 3362 minutes, and 11.615 hours. Two minutes following a 0.568 mg/kg dose of intravenous dipyridamole administered as a 4-minute infusion, the mean dipyridamole serum concentration is 4.61.3 mcg/mL. The average plasma protein binding of dipyridamole is approximately 99%, primarily to 1-glycoprotein. Dipyridamole is metabolized in the liver to the glucuronic acid conjugate and excreted with the bile. The average total body clearance is 2.33.5 mL/min/kg, with an apparent volume of distribution at a steady state of 12.5 L/kg and a central apparent volume of 35 liters.

Indications and usage

Dipyridamole injection is indicated as an alternative to exercise in thallium myocardial perfusion imaging for the evaluation of coronary artery disease in patients who cannot exercise adequately.

In a study of about 1100 patients who underwent coronary arteriography and dipyridamole-assisted thallium imaging, the results of both tests were interpreted blindly; and the sensitivity and specificity of the dipyridamole thallium study in predicting the angiographic outcome were calculated. The sensitivity of the dipyridamole test (true positive dipyridamole divided by the total number of patients with positive angiography) was about 85%. The specificity (true negative divided by the number of patients with negative angiograms) was about 50%.

In a subset of patients who had exercise thallium imaging as well as dipyridamole thallium imaging, sensitivity and specificity of the two tests were almost identical.

Contraindications

Hypersensitivity to dipyridamole.

Warnings

Serious adverse reactions associated with the administration of intravenous dipyridamole have included cardiac death, fatal and non-fatal myocardial infarction, ventricular fibrillation, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction, and bronchospasm. There have been reported cases of asystole, sinus node arrest, sinus node depression and conduction block. Patients with abnormalities of cardiac impulse formation/conduction or severe coronary artery disease may be at increased risk for these events.

In a study of 3911 patients given intravenous dipyridamole as an adjunct to thallium myocardial perfusion imaging, two types of serious adverse events were reported: 1) four cases of myocardial infarction (0.1%), two fatal (0.05%) and two non-fatal (0.05%); and 2) six cases of severe bronchospasm (0.2%). Although the incidence of these serious adverse events was small (0.3%, 10 of 3911), the potential clinical information to be gained through use of intravenous dipyridamole thallium imaging (see INDICATION AND USAGE noting the rate of false positive and false negative results) must be weighed against the risk to the patient. Patients with a history of unstable angina may be at a greater risk for severe myocardial ischemia. Patients with a history of asthma may be at a greater risk for bronchospasm during dipyridamole injection use.

When thallium myocardial perfusion imaging is performed with intravenous dipyridamole, parenteral aminophylline should be readily available for relieving adverse events such as bronchospasm or chest pain. Vital signs should be monitored during, and for 1015 minutes following, the intravenous infusion of dipyridamole and an electrocardiographic tracing should be obtained using at least one chest lead. Should severe chest pain or bronchospasm occur, parenteral aminophylline may be administered by slow intravenous injection (50100 mg over 3060 seconds) in doses ranging from 50 to 250 mg. In the case of severe hypotension, the patient should be placed in a supine position with the head tilted down if necessary, before administration of parenteral aminophylline. If 250 mg of aminophylline does not relieve chest pain symptoms within a few minutes, sublingual nitroglycerin may be administered. If chest pain continues despite use of aminophylline and nitroglycerin, the possibility of myocardial infarction should be considered. If the clinical condition of a patient with an adverse event permits a one minute delay in the administration of parenteral aminophylline, thallium-201 may be injected and allowed to circulate for one minute before the injection of aminophylline. This will allow initial thallium perfusion imaging to be performed before reversal of the pharmacologic effects of dipyridamole injection on the coronary circulation.

Precautions

(See Warnings )

Drug interactions

Oral maintenance theophylline and other xanthine derivatives such as caffeine may abolish the coronary vasodilatation induced by intravenous dipyridamole administration. This could lead to a false negative thallium imaging result. (See CLINICAL PHARMACOLOGYMechanism of Action ).

Myasthenia gravis patients receiving therapy with cholinesterase inhibitors may experience worsening of their disease in the presence of dipyridamole.

Carcinogenesis, mutagenesis, impairment of fertility

In studies in which dipyridamole was administered in the feed at doses of up to 75 mg/kg/day (9.4 times the maximum recommended daily human oral dose) in mice (up to 128 weeks in males and up to 142 weeks in females) and rats (up to 111 weeks in males and females), there was no evidence of drug related carcinogenesis. Mutagenicity tests of dipyridamole with bacterial and mammalian cell systems were negative. There was no evidence of impaired fertility when dipyridamole was administered to male and female rats at oral doses of up to 500 mg/kg/day (63 times ft1the maximum recommended daily human oral dose). A significant reduction in number of corpora lutea with consequent reduction in implantations and live fetuses was, however, observed at 1250 mg/kg/day.

Pregnancy category b

Reproduction studies performed in mice and rats at daily oral doses of up to 125 mg/kg (15.6 times the maximum recommended daily human oral dose) and in rabbits at daily oral doses of up to 20 mg/kg (2.5 times ft2the maximum recommended daily human oral dose) have revealed no evidence of impaired embryonic development due to dipyridamole. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human responses, this drug should be used during pregnancy only if clearly needed.

Nursing mothers

Dipyridamole is excreted in human milk.

Pediatric use

Safety and effectiveness in the pediatric population have not been established.

Adverse reactions

Adverse reaction information concerning intravenous dipyridamole is derived from a study of 3911 patients in which intravenous dipyridamole was used as an adjunct to thallium myocardial perfusion imaging and from spontaneous reports of adverse reactions and the published literature.

Serious adverse events (cardiac death, fatal and non-fatal myocardial infarction, ventricular fibrillation, asystole, sinus node arrest, symptomatic ventricular tachycardia, stroke, transient cerebral ischemia, seizures, anaphylactoid reaction and bronchospasm) are described above. (See WARNINGS ).

In the study of 3911 patients, the most frequent adverse reactions were: chest pain/angina pectoris (19.7%), electrocardiographic changes (most commonly ST-T changes) (15.9%), headache (12.2%), and dizziness (11.8%).

Adverse reactions occurring in greater than 1% of the patients in the study are shown in the following table:

Incidence (%)
of Drug-Related
Adverse Events
Chest pain/angina pectoris 19.7
Headache 12.2
Dizziness 11.8
Electrocardiographic
Abnormalities/ST-T changes 7.5
Electrocardiographic
Abnormalities/Extrasystoles 5.2
Hypotension 4.6
Nausea 4.6
Flushing 3.4
Electrocardiographic
Abnormalities/Tachycardia 3.2
Dyspnea 2.6
Pain Unspecified 2.6
Blood Pressure Lability 1.6
Hypertension 1.5
Paresthesia 1.3
Fatigue 1.2

Less common adverse reactions occurring in 1% or less of the patients within the study included:

Cardiovascular system

Electrocardiographic abnormalities unspecified (0.8%), arrhythmia unspecified (0.6%), palpitation (0.3%), ventricular tachycardia (0.2%, see WARNINGS ), bradycardia (0.2%), myocardial infarction (0.1%, see WARNINGS ), AV block (0.1%), syncope (0.1%), orthostatic hypotension (0.1%), atrial fibrillation (0.1%), supraventricular tachycardia (0.1%), ventricular arrhythmia unspecified (0.03%, see WARNINGS ), heart block unspecified (0.03%), cardiomyopathy (0.03%), edema (0.03%).

Central and peripheral nervous system

Hypothesia (0.5%), hypertonia (0.3%), nervousness/anxiety (0.2%), tremor (0.1%), abnormal coordination (0.03%), somnolence (0.03%), dysphonia (0.03%), migraine (0.03%), vertigo (0.03%).

Gastrointestinal system

Dyspepsia (1.0%), dry mouth (0.8%), abdominal pain (0.7%), flatulence (0.6%), vomiting (0.4%), eructation (0.1%), dysphagia (0.03%), tenesmus (0.03%), appetite increased (0.03%).

Respiratory system

Pharyngitis (0.3%), bronchospasm (0.2%, see WARNINGS ), hyperventilation (0.1%), rhinitis (0.1%), coughing (0.03%), pleural pain (0.03%).

Other

Myalgia (0.9%), back pain (0.6%), injection site reaction unspecified (0.4%), diaphoresis (0.4%), asthenia (0.3%), malaise (0.3%), arthralgia (0.3%), injection site pain (0.1%), rigor (0.1%), earache (0.1%), tinnitus (0.1%), vision abnormalities unspecified (0.1%), dysgeusia (0.1%), thirst (0.03%), depersonalization (0.03%), eye pain (0.03%), renal pain (0.03%), perineal pain (0.03%), breast pain (0.03%), intermittent claudication (0.03%), leg cramping (0.03%). In additional postmarketing experience, there have been rare reports of allergic reaction including urticaria, pruritus, dermatitis and rash.

Overdosage

No cases of overdosage in humans have been reported. It is unlikely that overdosage will occur because of the nature of use (i.e., single intravenous administration in controlled settings). See WARNINGS .

Dosage and administration

The dose of intravenous dipyridamole as an adjunct to thallium myocardial perfusion imaging should be adjusted according to the weight of the patient. The recommended dose is 0.142 mg/kg/minute (0.57 mg/kg total) infused over 4 minutes. Although the maximum tolerated dose has not been determined, clinical experience suggests that a total dose beyond 60 mg is not needed for any patient.

Prior to intravenous administration, dipyridamole injection should be diluted in at least a 1:2 ratio with 0.45% sodium chloride injection, 0.9% sodium chloride injection, or 5% dextrose injection for a total volume of approximately 20 to 50 mL. Infusion of undiluted dipyridamole injection may cause local irritation.

Thallium-201 should be injected within 5 minutes following the 4-minute infusion of dipyridamole injection.

Do not mix dipyridamole injection with other drugs in the same syringe or infusion container.

Parenteral drug product should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

How supplied

Dipyridamole Injection for intravenous injection is available as follows:

NDC Number Dipyridamole Injection Volume
0703-1652-04 5 mg/mL 2 mL in a 2 mL vial
0703-1654-03 5 mg/mL 10 mL in a 10 mL vial

2 mL vials are packaged 25 per shelf carton.

10 mL vials are packaged 10 per shelf carton.

Storage and handling section

Store between 1525C (5977F). Protect from light. Avoid freezing.

Only use in myocardial imaging. For IV injection only. Dilute before use.

Spl unclassified section

Issued: April, 2009
Teva Parenteral Medicines, Inc.
Irvine, CA 92618

Ingredients and appearance - Product information

Dipyridamole injection- Dipyridamole

Product information

Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC: 0703-1652
Route of Administration Intravenous

Active Ingredient/Active Moiety

Ingredient Name Strength
Dipyridamole ( UNII: 64ALC7F90C)( Dipyridamole - UNII: 64ALC7F90C ) 5 mgin 1 mL

Inactive Ingredients

Ingredient Name Code
Polyethylene glycol 600 ( UNII: NL4J9F21N9)
Tartaric acid ( UNII: W4888I119H)
Hydrochloric acid ( UNII: QTT17582CB)

Product Characteristics

Marketing Information

Marketing Category Application Number or Monograph Citation Territorial Authority Marketing Start Date
ANDA ANDA074952 USA

Dipyridamole injection- Dipyridamole

Product information

Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC: 0703-1654
Route of Administration Intravenous

Active Ingredient/Active Moiety

Ingredient Name Strength
Dipyridamole ( UNII: 64ALC7F90C)( Dipyridamole - UNII: 64ALC7F90C ) 5 mgin 1 mL

Inactive Ingredients

Ingredient Name Code
Polyethylene glycol 600 ( UNII: NL4J9F21N9)
Tartaric acid ( UNII: W4888I119H)
Hydrochloric acid ( UNII: QTT17582CB)

Product Characteristics

Marketing Information

Marketing Category Application Number or Monograph Citation Territorial Authority Marketing Start Date
ANDA ANDA074952 USA

Labeler - Teva Parenteral Medicines, Inc( 794362533)

Establishment

Name ID/FEI Business Operations
Teva Parenteral Medicines, Inc 794362533 MANUFACTURE()

Principal display panel - 10 ml label

NDC 0703-1654-01
Rx only

Dipyridamole
Injection

50 mg/10 mL
(5 mg/mL)

10 mL Single Dose Vial
Only Use In Myocardial Imaging
For IV Injection Only
Dilute Before Use

TEVA

Calculation based on assumed body weight of 50 kg.
Calculation based on assumed body weight of 50 kg.